American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2014
Disease-specific T Helper Cell Polarizing Function of Lesional Dendritic Cells in Different Types of Chronic Rhinosinusitis with Nasal Polyps.
Although eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit distinct T-helper (Th) responses, the underlying mechanisms remain unclear. ⋯ Distinct subsets of lesional DCs were found in eosinophilic and noneosinophilic CRSwNP, where OX40L/PD-L1(+) lesional DCs in eosinophilic CRSwNP could prime Th2 cells, whereas the low OX40L/PD-L1-expressing lesional DCs in noneosinophilic CRSwNP primarily induced Th1/Th17 cells.