American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2015
New Risk Factors for Adult Onset Incident Asthma: A Nested Case Control Study of Host Antioxidant Defense.
Host antioxidant defense, consisting of enzymatic antioxidant activity and nonenzymatic antioxidant micronutrients, is implicated in asthma pathogenesis. Studies of antioxidant defense and adult incident asthma have either used measures of antioxidants estimated from questionnaires or not considered enzymatic aspects of host defense. ⋯ In this prospective study, α-tocopherol, within normal reference ranges, and PAF-AH enzymatic activity were associated with decreased asthma development. These modifiable risk factors may be an effective strategy to test for primary asthma prevention.