American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2015
Randomized Controlled Trial Multicenter StudyA Non-Steroidal Glucocorticoid Receptor Agonist Inhibits Allergen-Induced Late Asthmatic Responses.
Effective antiinflammatory therapies are needed for the treatment of asthma, but preferably without the systemic adverse effects of glucocorticosteroids. ⋯ Seven-day treatment with inhalation of the nonsteroidal glucocorticoid receptor agonist AZD5423 effectively reduced allergen-induced responses in subjects with mild allergic asthma. Clinical trial registered with www.clinicaltrials.gov (NCT01225549).