American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2015
Multicenter Study Clinical TrialTiming of Low Tidal Volume Ventilation and ICU Mortality in ARDS: A Prospective Cohort Study.
Reducing tidal volume decreases mortality in acute respiratory distress syndrome (ARDS). However, the effect of the timing of low tidal volume ventilation is not well understood. ⋯ Higher tidal volumes shortly after ARDS onset were associated with a greater risk of ICU mortality compared with subsequent tidal volumes. Timely recognition of ARDS and adherence to low tidal volume ventilation is important for reducing mortality. Clinical trial registered with www.clinicaltrials.gov (NCT 00300248).
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Am. J. Respir. Crit. Care Med. · Jan 2015
Randomized Controlled Trial Multicenter StudyA Non-Steroidal Glucocorticoid Receptor Agonist Inhibits Allergen-Induced Late Asthmatic Responses.
Effective antiinflammatory therapies are needed for the treatment of asthma, but preferably without the systemic adverse effects of glucocorticosteroids. ⋯ Seven-day treatment with inhalation of the nonsteroidal glucocorticoid receptor agonist AZD5423 effectively reduced allergen-induced responses in subjects with mild allergic asthma. Clinical trial registered with www.clinicaltrials.gov (NCT01225549).
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Am. J. Respir. Crit. Care Med. · Jan 2015
Multicenter StudyThe Association Between ARDS, Delirium, and In-hospital Mortality in ICU Patients.
Both acute respiratory distress syndrome (ARDS) and intensive care unit (ICU) delirium are associated with significant morbidity and mortality. However, the risk of delirium and its impact on mortality in ARDS patients is unknown. ⋯ Our findings suggest that ARDS is associated with a greater risk for ICU delirium than mechanical ventilation alone, and that the association between ARDS and in-hospital mortality is weakened after adjusting for delirium and coma. Future studies are needed to determine if prevention and reduction of delirium in ARDS patients can improve outcomes.