American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2015
Editorial CommentAn Old World's View on a New World's Solution.
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Am. J. Respir. Crit. Care Med. · Feb 2015
Randomized Controlled Trial Multicenter Study Comparative StudyDaily Rifapentine for Treatment of Pulmonary Tuberculosis: a Randomized, Dose-ranging Trial.
Rifapentine has potent activity in mouse models of tuberculosis chemotherapy but its optimal dose and exposure in humans are unknown. ⋯ Daily rifapentine was well-tolerated and safe. High rifapentine exposures were associated with high levels of sputum sterilization at completion of intensive phase. Further studies are warranted to determine if regimens that deliver high rifapentine exposures can shorten treatment duration to less than 6 months. Clinical trial registered with www.clinicaltrials.gov (NCT 00694629).
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Am. J. Respir. Crit. Care Med. · Feb 2015
Multicenter Study Comparative StudyClinical Features of Childhood Primary Ciliary Dyskinesia By Genotype and Ultrastructural Phenotype.
The relationship between clinical phenotype of childhood primary ciliary dyskinesia (PCD) and ultrastructural defects and genotype is poorly defined. ⋯ Lung disease was heterogeneous across all ultrastructural and genotype groups, but worse in those with IDA/CA/MTD ultrastructural defects, most of whom had biallelic mutations in CCDC39 or CCDC40.
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Am. J. Respir. Crit. Care Med. · Feb 2015
Comparative StudyDeveloping a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock.
Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling. Identifying the subclasses in real time has theranostic implications, given the potential for immune-enhancing therapies and controversies surrounding adjunctive corticosteroids for septic shock. ⋯ We developed and tested a gene expression-based classification method for pediatric septic shock that meets the time constraints of the critical care environment, and can potentially inform therapeutic decisions.