American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2015
Letter Randomized Controlled TrialEarly Peripheral Perfusion-guided Fluid Therapy in Patients with Septic Shock.
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Am. J. Respir. Crit. Care Med. · Feb 2015
Randomized Controlled Trial Multicenter Study Comparative StudyDaily Rifapentine for Treatment of Pulmonary Tuberculosis: a Randomized, Dose-ranging Trial.
Rifapentine has potent activity in mouse models of tuberculosis chemotherapy but its optimal dose and exposure in humans are unknown. ⋯ Daily rifapentine was well-tolerated and safe. High rifapentine exposures were associated with high levels of sputum sterilization at completion of intensive phase. Further studies are warranted to determine if regimens that deliver high rifapentine exposures can shorten treatment duration to less than 6 months. Clinical trial registered with www.clinicaltrials.gov (NCT 00694629).