American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Apr 2016
HIP1 is an Early-stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated EMT.
Non-small cell lung cancer (NSCLC) carries a poor survival rate mainly because of metastasis. However, the molecular mechanisms that govern NSCLC metastasis have not been described. Because huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis, we tested the involvement of HIP1 in NSCLC progression and metastasis. ⋯ HIP1 serves as an early-stage prognostic biomarker and a metastatic suppressor. Reduced expression during AdCA progression can relieve HIP1 suppression of Akt-mediated epithelial-mesenchymal transition and thereby lead to development of late metastases and poor prognosis.