American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Apr 2016
Randomized Controlled TrialLung Deflation and Cardiovascular Structure and Function in COPD: A Randomized Controlled Trial.
Patients with chronic obstructive pulmonary disease develop increased cardiovascular morbidity with structural alterations. ⋯ Pharmacologic treatment of chronic obstructive pulmonary disease has consistent beneficial and plausible effects on cardiac function and pulmonary vasculature that may contribute to favorable effects of inhaled therapies. Future studies should investigate the effect of prolonged lung deflation on intrinsic myocardial function. Clinical trial registered with www.clinicaltrials.gov (NCT 01691885).