Acta clinica Croatica
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Acta clinica Croatica · Apr 2023
ASSOCIATION BETWEEN HIGH MOBILITY GROUP BOX 1 PROTEIN GENE (rs41369348) POLYMORPHISM AND IMMUNOGLOBULIN A VASCULITIS IN CHILDREN.
Immunoglobulin A vasculitis (IgAV) or Henoch-Schönlein purpura is the most prevalent systemic small vessel vasculitis in childhood. High mobility group box 1 protein (HMBG1) is a pleiotropic cytokine that functions as a pro-inflammatory signal, important for the activation of antigen-presenting cells and propagation of inflammation. HMGB1 is implicated in the pathophysiology of a variety of inflammatory diseases. ⋯ Although there was a higher frequency of heterozygous A/delA genotype of this gene polymorphism in IgAV group as compared with control group, no genotype difference was observed between these two groups. No statistically significant genotype differences were disclosed when patients with different IgAV clinical features were compared. In conclusion, in this study, polymorphism rs41369348 for HMGB1 was not associated with increased susceptibility to childhood IgAV, its severity or different clinical manifestations.
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Acta clinica Croatica · Apr 2023
EPIDEMIOLOGICAL CHARACTERISTICS AND FACTORS ASSOCIATED WITH MORTALITY IN SEVERELY BURNED PATIENTS - CROATIAN NATIONAL BURN CENTER REPORT.
The authors conducted a single-center retrospective study during the last 6.5 years. The study aimed to describe demographic data of burn patients in the Croatian Burn Center and investigate factors affecting mortality for the first time after the Center was established. The study included 109 severely burned patients with a total body surface area (TBSA) burned ≥20%, admitted to the burn intensive care unit. ⋯ With an increase of TBSA by 1%, the odds of lethal outcome are expected to increase by 7% (p<0.0001). Other variables included in the analysis did not show statistical significance. TBSA percentage is a well-known predictor of mortality and numerous studies indicate an association between comorbidities and mortality but there are conflicting results about other demographic factors and injury characteristics.
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Acta clinica Croatica · Apr 2023
Case ReportsDILEMMAS ABOUT THE SELECTION OF ANESTHESIA FOR ELECTIVE CESAREAN SECTION IN PREGNANT WOMEN WITH MYOTONIC DYSTROPHY TYPE 2 AND SUSPECTED von WILLEBRAND DISEASE: A CASE REPORT.
With advancement of medicine in the field of diagnostics and treatment of women suffering from certain genetic disorders, more and more women have attained reproductive age and desired fertility. Maintaining pregnancy, as well as bringing it to an end poses a real challenge not only for obstetricians, but also for anesthesiologists involved in the procedure. ⋯ It is acknowledged that both diseases have their own peculiarities and specificities related to anesthesia and require careful consideration when it comes to selecting it. Bearing in mind the advantages and disadvantages of certain types of anesthesia, we believe that in this case, general anesthesia was a better choice compared to the regional techniques of anesthesia.
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Acta clinica Croatica · Apr 2023
OPTIMIZATION OF PRE-HOSPITAL FIRST AID MANAGEMENT STRATEGIES FOR PATIENTS WITH INFECTIOUS DISEASES IN HUIZHOU CITY USING DEEP LEARNING ALGORITHM.
The aim of the study was to optimize the pre-hospital first aid management strategy for patients with infectious diseases in Huizhou city, which is expected to provide a basis for the epidemic prevention and control, to save lives, and increase the pre-hospital first aid efficiency. At the Department of Emergency, Huizhou Third People's Hospital as the research subject, the common pre-hospital first aid procedure for infectious diseases was identified. The Petri net was used to model and determine the execution time of each link of the pre-hospital first aid process. ⋯ In terms of the emergency path, deep learning was combined with the reinforcement learning model to construct the reinforcement learning model for ambulance path planning. Isomorphic Markov chain analysis revealed that the patient status when returning to the hospital, the time needed for the ambulance to come to designated location, and the on-site treatment were the main problems in the first aid process, and the time needed for the pre-hospital first aid process was reduced by 25.17% after optimization. In conclusion, Petri net and isomorphic Markov chain can optimize the pre-hospital first aid management strategies for patients with infectious diseases, and the use of deep learning algorithm can effectively plan the emergency path, achieving intelligent and informationalized pre-hospital transfer, which provides a basis for reducing the suffering, mortality, and disability rate of patients with infectious diseases.
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Acta clinica Croatica · Apr 2023
VOICE CONDITION FOLLOWING SHORT-TERM ENDOTRACHEAL INTUBATION IN HEAD AND NECK SURGERY: STUDY PROTOCOL FOR CLINICAL TRIAL.
Endotracheal intubation is an airway management procedure commonly performed under general anesthesia. It is linked with postoperative voice changes. The incidence and reasons of hoarseness and vocal cord injury are not very well investigated, especially after short-term anesthesia and intubation in head and neck surgery. ⋯ Endotracheal intubation is a safe method of airway management although it can temporarily alter a patient's voice quality. It is not known how much of this is the result of anesthesia, general condition of the patient, or surgery. This trial is expected to shed some light on this issue.