Folia neuropathologica
-
Folia neuropathologica · Jan 2012
ReviewSepsis and septic encephalopathy: characteristics and experimental models.
The inflammation is a response of the organism to damaging factors and leads to the limitation of the tissue destruction. During the inflammatory process, there is stimulation of the immune system as well as other tissue cells. However, sometimes this reaction is excessive and can bring to the sepsis and development of multiorgan insufficiency. ⋯ Still increasing concern of SE brought to the development of several animal models of this syndrome, which made possible detailed recognition of phenomena accompanying of septic encephalopathy. They include direct administration of endotoxins, or surgical intervention within the abdominal cavity. Every presented experimental model has advantages and weakness, but they make possible the modeling of the inflammatory reaction and multidirectional examining of accompanying phenomena.