Annals of internal medicine
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Randomized Controlled Trial
Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study.
Insufficient sleep increases the risk for insulin resistance, type 2 diabetes, and obesity, suggesting that sleep restriction may impair peripheral metabolic pathways. Yet, a direct link between sleep restriction and alterations in molecular metabolic pathways in any peripheral human tissue has not been shown. ⋯ National Institutes of Health.
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Randomized Controlled Trial Multicenter Study
Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial.
Currently, there is no proven alternative therapy for patients with familial Mediterranean fever (FMF) that is resistant to or intolerant of colchicine. Interleukin-1 is a key proinflammatory cytokine in FMF. ⋯ U.S. Food and Drug Administration, Office of Orphan Products Development.
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In older adults, current equations to estimate glomerular filtration rate (GFR) are not validated and may misclassify elderly persons in terms of their stage of chronic kidney disease. ⋯ Kuratorium für Dialyse und Nierentransplatation (KfH) Foundation of Preventive Medicine.
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Little information exists about what primary care physicians (PCPs) and patients experience if patients are invited to read their doctors' office notes. ⋯ The Robert Wood Johnson Foundation, the Drane Family Fund, the Richard and Florence Koplow Charitable Foundation, and the National Cancer Institute.