Annals of internal medicine
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Randomized Controlled Trial
Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study.
Insufficient sleep increases the risk for insulin resistance, type 2 diabetes, and obesity, suggesting that sleep restriction may impair peripheral metabolic pathways. Yet, a direct link between sleep restriction and alterations in molecular metabolic pathways in any peripheral human tissue has not been shown. ⋯ National Institutes of Health.
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Randomized Controlled Trial Multicenter Study
Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial.
Currently, there is no proven alternative therapy for patients with familial Mediterranean fever (FMF) that is resistant to or intolerant of colchicine. Interleukin-1 is a key proinflammatory cytokine in FMF. ⋯ U.S. Food and Drug Administration, Office of Orphan Products Development.