Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.
Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection. ⋯ National Institutes of Health.
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Comment Randomized Controlled Trial
In patients with CHD, a Mediterranean vs. low-fat diet reduced major CV events at 7 y.
Delgado-Lista J, Alcala-Diaz JF, Torres-Peña JD, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. Lancet. 2022;399:1876-85. 35525255.
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Randomized Controlled Trial
Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical Trial.
Immunoassays for determining past SARS-CoV-2 infection have not been systematically evaluated in vaccinated persons in comparison with unvaccinated persons. ⋯ National Institute of Allergy and Infectious Diseases of the National Institutes of Health.
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Comment Randomized Controlled Trial
In IgA nephropathy, oral methylprednisolone reduced adverse kidney outcomes but increased adverse events.
Lv J, Wong MG, Hladunewich MA, et al. Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: the TESTING randomized clinical trial. JAMA. 2022;327:1888-98. 35579642.
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Comment Randomized Controlled Trial
In COVID-19 acute hypoxemia, awake prone positioning vs. usual care did not reduce intubation at 30 d.