Annals of surgery
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Randomized Controlled Trial Multicenter Study
A Prospective, Randomized Phase II Study of Adjuvant Gemcitabine Versus S-1 After Major Hepatectomy for Biliary Tract Cancer (KHBO 1208): Kansai Hepato-Biliary Oncology Group.
To evaluate each arm independently and compare adjuvant gemcitabine (GEM) and S-1 chemotherapy after major hepatectomy (hemihepatectomy or trisectionectomy) for biliary tract cancer (BTC). ⋯ The comparison of the survival of the 2 groups revealed that adjuvant S-1 therapy may be superior to adjuvant GEM therapy after major hepatectomy for BTC.
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Multicenter Study Comparative Study
Determinants of Severity in Acute Pancreatitis: A Nation-wide Multicenter Prospective Cohort Study.
The aim of this study was to compare and validate the different classifications of severity in acute pancreatitis (AP) and to investigate which characteristics of the disease are associated with worse outcomes. ⋯ The RAC and DBC both signify an advance in the description and differentiation of AP patients. Herein, we describe the complications of the disease independently associated to morbidity and mortality. Our findings are valuable not only when designing future studies on AP but also for the improvement of current classifications.
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Multicenter Study Comparative Study
Benchmarks in Pancreatic Surgery: A Novel Tool for Unbiased Outcome Comparisons.
To use the concept of benchmarking to establish robust and standardized outcome references after pancreatico-duodenectomy (PD). ⋯ The proposed outcome benchmarks for PD, established in a large-scale international patient cohort and tested in 2 different cohorts, may allow for meaningful comparisons between different patient cohorts, centers, countries, and surgical techniques.
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Multicenter Study
Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis.
To investigate trends in long-term graft and patient outcomes following liver transplantation using grafts from donors ≥60 years old. ⋯ This study demonstrates significant improvement in transplant outcomes with donor grafts ≥60-years old and supports increased but judicious use of extended criteria donors liver grafts. Improved patient selection and reduction in cold ischemia time appear to be contributing factors.
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Randomized Controlled Trial Multicenter Study
Targeted Muscle Reinnervation Treats Neuroma and Phantom Pain in Major Limb Amputees: A Randomized Clinical Trial.
To compare targeted muscle reinnervation (TMR) to "standard treatment" of neuroma excision and burying into muscle for postamputation pain. ⋯ In this first surgical RCT for the treatment of postamputation pain in major limb amputees, TMR improved PLP and trended toward improved residual limb pain compared with conventional neurectomy.