Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Jul 2020
Case ReportsNeurological Sequelae in Youngest Adult Behcet's Disease Patient on Infliximab.
Neuro-Behcet's disease is a rare neurological complication of Behcet's disease presenting between second and fourth decades of life. The etiology of Behcet's disease is still unknown but genetic predisposition has been described to play a role. The disease is reported more in males than females. ⋯ Treatment includes anti-inflammatory drugs and immunotherapeutics. Our case is the youngest adult reported so far and is an unusual presentation of neuro-Behcet's disease, as the patient was already in remission and on infliximab infusion. Key Words: Neuro-Behcet's, MRI, Infliximab.
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J Coll Physicians Surg Pak · Jul 2020
Randomized Controlled TrialTranscranial Pulsed Ultrasound with Alteplase Intravenous Thrombolysis for Vascular Recanalisation in Acute Ischemic Stroke.
The objective of study was to investigate the effect of transcranial pulsed ultrasound combined with alteplase on treatment of vascular recanalisation in acute ischemic stroke patients. Eighty-two patients were randomly divided equally into two groups. Group A was treated with transcranial pulsed ultrasound combined with alteplase intravenous thrombolysis. ⋯ At 90 days after treatment, rate of favourable prognosis [(modified rankin scale (mRS) ≤2 points)] of group A was higher than that of group B (p=0.001). Transcranial pulsed ultrasound combined with alteplase intravenous thrombolytic treatment can improve vascular recanalization rate and prognosis. Key Words: Transcranial pulsed ultrasound, Acute ischemic stroke, Alteplase, Thrombolysis, Vascular recanalisation.
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J Coll Physicians Surg Pak · Jul 2020
Observational StudyFrequency of COVID-19 IgG Antibodies among Special Police Squad Lahore, Pakistan.
To find out the sero-prevalence of COVID-19 IgG antibodies among policemen performing duties at high risk areas of Lahore, Pakistan. ⋯ COVID-19 IgG antibody reactive cases may not show any symptoms. Police force is at high risk of exposure. Serosurveys can help to find the spread of infection in the community and aid in planning healthcare strategies. Key Words: COVID-19, SARS CoV-2, Seroprevalence, Pandemic, Asymptomatic cases.
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J Coll Physicians Surg Pak · Jul 2020
Does Subclinical Hypothyroidism Affect Dynamic Thiol / Disulfide Homeostasis and İschemia-modified Albumin Levels in Children?
To determine the effects of subclinical hypothyroidism on oxidative stress in children. ⋯ Subclinical hypothyroidism may be related to the impairment of IMA, and have a neutral effect on thiol/disulfide balance. Further research is needed to explain the effects of oxidative stress in subclinical hypothyroidism. Key Words: Subclinical hypothyroidism, Childhood, Oxidative stress.
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J Coll Physicians Surg Pak · Jul 2020
Observational StudyComparison of Estimated Glomerular Filtration Rate with Both Serum Creatinine and Cystatin C (eGFRcr-cys) versus Single Analyte (eGFRcr or eGFRcys) Using CKD-EPI and MDRD Equations in Tertiary Care Hospital Settings.
To assess and compare the glomerular filtration rate (eGFR) estimated through MDRD and CKD-EPIcr equations in early and late stages of chronic kidney disease on biochemical marker creatinine (eGFRcr), cystatin C (eGFRcys); and combined (eGFRcr-cys), using CKD-EPI equation. ⋯ eGFR calculated by CKD-EPI equation considered as better diagnostic efficient response than MDRD equation in diagnosis and staging of chronic kidney disease. While applying CKD-EPI equation for measurement of eGFR, eGFRcr-cys performs better than any of eGFRcr or eGFRcys at all stages of CKD. Key Words: Estimated glomerular filtration rate (eGFR), Cystatin C (Cys), Creatinine (Cr), Creatinine clearance (CrCl), CKD-EPI equation, MDRD equation.