Dementia and geriatric cognitive disorders
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Dement Geriatr Cogn Disord · Jan 2008
High risk of cognitive and functional decline after postoperative delirium. A three-year prospective study.
The aim of the study was to investigate the association of postoperative delirium with the outcomes of cognitive impairment, functional disability and death. ⋯ The present study confirms a poor prognosis after delirium in elderly patients. The findings suggest that delirium does not simply persist for a certain time but also predicts a future cognitive decline with an increased risk of dementia.
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Dement Geriatr Cogn Disord · Jan 2008
The Severe Cognitive Impairment Rating Scale--an instrument for the assessment of cognition in moderate to severe dementia patients.
This study aimed to develop a brief, reliable and valid test for cognitive function of severely demented patients. ⋯ The Severe Cognitive Impairment Rating Scale is a valid and reliable test for evaluating the cognitive function of advanced AD patients.
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Dement Geriatr Cogn Disord · Jan 2008
The extended tau haplotype and the age of onset of dementia in Down syndrome.
Most people with Down syndrome (DS) develop Alzheimer's disease (AD). The extended tau haplotype has been linked to AD. In this study, we examined the haplotype's effect on the age of onset of AD in DS. ⋯ Even in a condition driven by excess amyloid pathology, factors affecting tau are also important and should be considered as potential treatment targets.
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Dement Geriatr Cogn Disord · Jan 2008
Homocysteine and C-reactive protein are not markers of cognitive impairment in patients with major cardiovascular disease.
Raised concentrations of plasma homocysteine and C-reactive protein (CRP) are associated with vascular disease and have also been implicated as independent risk factors for cognitive impairment in population studies. ⋯ PreCI and POCD are present in a substantial proportion of patients undergoing CABG surgery but there is no independent association with either baseline homocysteine or CRP levels. It is possible that cognitive impairment may result from the vascular disease rather than a direct association with either homocysteine or CRP.