British journal of anaesthesia
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Randomized Controlled Trial Comparative Study
Xenon anaesthesia for patients undergoing off-pump coronary artery bypass graft surgery: a prospective randomized controlled pilot trial†.
Off-pump coronary artery bypass (OPCAB) surgery carries a high risk for haemodynamic instability and perioperative organ injury. Favourable haemodynamic effects and organ-protective properties could render xenon an attractive anaesthetic for OPCAB surgery. The primary aim of this study was to assess whether xenon anaesthesia for OPCAB surgery is non-inferior to sevoflurane anaesthesia with regard to intraoperative vasopressor requirements. ⋯ ClinicalTrials.gov (NCT01757106) and EudraCT (2012-002316-12).
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Randomized Controlled Trial
Effect of acute cigarette smoking on gastric contents in regular smoker volunteers. A prospective randomized cross-over study.
The authors sought to assess the effect of acute smoking on gastric contents in regular smoker volunteers. The primary endpoint was the variation in antral area during the 120-min study period after cigarette smoking. ⋯ NCT 02080598.
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Randomized Controlled Trial
Randomized controlled trial of stroke volume optimization during elective major abdominal surgery in patients stratified by aerobic fitness.
The benefits of stroke volume optimization during surgery are unclear, with recent data not replicating the positive effects of earlier studies. ⋯ ISRCTN21597243.
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Randomized Controlled Trial
Routine screening for pain combined with a pain treatment protocol in head and neck cancer: a randomised controlled trial.
We compared the effectiveness and cost of a pain screening and treatment program, with usual care in head and neck cancer patients with significant pain. ⋯ There was no difference in the Pain Severity Index between the two groups. However there were significant improvements in the intervention group in patient satisfaction and PMI. The pain screening process itself was effective. Sufficient benefit was demonstrated as a result of the intervention to allow continued development of pain treatment pathways, rather than allowing pain treatment to be left to nonformalised ad hoc arrangements.