British journal of anaesthesia
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Editorial Comment
Consciousness and the outside world: is there anyone listening?
Sedated patients have graded levels of consciousness and perceptual connection with the outside world. Disconnection is associated with widespread changes in the electroencephalogram, whereas full unconsciousness is linked with decreased activity specifically in the deep midline regions of the brain. These findings can be interpreted within the predictive coding model of consciousness as differences in model generation vs discrepancy detection. Anaesthetists should be cognisant that apparently unresponsive patients might still have some ongoing partially disconnected consciousness activity.
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Editorial Comment
Realising the potential of functional imaging to reveal brain changes after anaesthesia and surgery.
We highlight the ability of functional brain imaging to detect changes in human brain function, even when changes are not seen in cognitive testing. These imaging changes are plausible as they correlate with known activity changes in carriers of APOE4, a genetic variant associated with increased risk for Alzheimer's disease. However, to realise the potential of functional imaging for perioperative neurocognitive disorders, collaborations similar to the Alzheimer's Disease Neuroimaging Initiative (ADNI) with open data sharing will be required. For the practicing anaesthesiologist, we believe that postoperative cognitive issues are important topics to discuss during the informed consent process.
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Current or recent infection with SARS-CoV-2 increases the risk of perioperative morbidity and mortality. Consensus guidelines recommend delaying elective major surgery after acute SARS-CoV-2 infection for 7 or 8 weeks. However, because of the growing backlog of untreated surgical disease and the potential risks of delaying surgery, surgical services may be under pressure to reduce this period. Here, we discuss the risks and benefits of delaying surgery for patients with current or recent SARS-CoV-2 infection in the context of the evolving COVID-19 pandemic, the limited evidence supporting delays to surgery, and the need for more research in this area.
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Editorial Comment
Silver linings: will the COVID-19 pandemic instigate long overdue mental health support services for healthcare workers?
A study in this month's journal adds to the growing body of evidence regarding the potential mental health impacts on frontline healthcare staff working during the COVID-19 pandemic. As clinical academics representing critical care, nursing, and medicine, and a psychologist guiding support for frontline health and social workers, we offer our perspectives on this study. We discuss the balance between pragmatic and rigorous data collection on this topic and offer perspectives on the observed differential impact on nurses. Finally, we suggest that the pandemic might have a positive effect by instigating more robust mental health support services for National Health Service workers.
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Clinical practice guidelines are increasingly important to guide clinical care. However, they can vary widely in quality, and many recommendations are based on low-level evidence. The COVID-19 pandemic highlighted the need for new flexible formats for rigorously developed guidelines. Future guideline development should be standardised, graded, registered, and updated to ensure that they are 'living' works in progress.