International journal of clinical practice
-
Int. J. Clin. Pract. · Oct 2007
Multicenter Study Clinical TrialOnce-daily OROS hydromorphone for the management of chronic nonmalignant pain: a dose-conversion and titration study.
The use of opioid analgesics for patients with chronic nonmalignant pain is becoming more widely accepted, and long-acting formulations are an important treatment option. ⋯ Patients with chronic nonmalignant pain who had been receiving opioid therapy easily underwent conversion to OROS hydromorphone, with no loss of efficacy or increase in adverse events.