International journal of clinical practice
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Int. J. Clin. Pract. · Apr 2021
Meta AnalysisPrevalence of persistent vegetative state compared to recovery, disability, and death in subjects with severe traumatic brain injury: A meta-analysis.
The persistent vegetative state has drawn considerable attention since it is the poorest result apart from mortality in subjects with severe traumatic brain injury. This meta-analysis was performed to evaluate its prevalence compared to recovery, disability, and death 6 months post severe traumatic brain injury. ⋯ However, persistent vegetative state is the poorest result apart from mortality in subjects with severe traumatic brain injury. Its prevalence is lower than the recovery, disability, and death even in developing counties with its lower healthcare services. The prevalence was variable over time and higher in developing countries. This relationship forces us to recommend improving healthcare services to the extent that a persistent vegetative state could be avoided as much as possible.
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Int. J. Clin. Pract. · Apr 2021
Review Meta AnalysisSerum lipids and the pathogenesis of Parkinson's disease: A systematic review and meta-analysis.
The role of serum lipids in the pathogenesis of Parkinson's disease (PD) remains unclear, and the results of previous reports remain conflicting. We aimed to conduct this systematic review and meta-analysis to identify the potential relationships of blood lipids and the pathogenesis of PD. ⋯ TG serum levels are significantly lower in PD patients, more studies are needed to further elucidate role of lipid in the PD development.
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Int. J. Clin. Pract. · Apr 2021
ReviewDo morbidity measures predict decline of activities of daily living and instrumental activities of daily living among older inpatients? A systematic review.
Older adults often suffer from multimorbidity, which results in hospitalisations. These are often associated with poor health outcomes such as functional dependence and mortality. The aim of this review was to summarise the current literature on the capacities of morbidity measures in predicting activities of daily living (ADL) and instrumental activities of daily living (IADL) amongst inpatients. ⋯ Morbidity measures are poor predictors for ADL or IADL decline amongst older inpatients and follow-up duration does not alter the performance of morbidity measures.
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Int. J. Clin. Pract. · Apr 2021
ReviewShifting the treatment paradigm in idiopathic overactive bladder.
Overactive Bladder (OAB) is a common condition that is known to have a significant impact on Health Related Quality of Life (HRQoL). Whilst all patients will initially benefit from lifestyle modifications and behavioural therapy in the first instance drug therapy remains integral in management pathways. The purpose of this review paper is to reappraise the evidence based approach to the management of OAB in addition to exploring a new treatment algorithm for the escalation of treatment in those patients with refractory symptoms. ⋯ We propose a new, evidence based, treatment algorithm for the management of OAB in patients who remain refractory to first line therapy.
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Int. J. Clin. Pract. · Apr 2021
Randomized Controlled TrialThe Effects of Elaeagnus angustifolia L. On Lipid and Glycemic Profiles and Cardiovascular Function in Menopausal Women: A Double-Blind, Randomized, Placebo-Controlled Study.
The reduced production of ovarian hormones is considered to be the cause of an increase in the incidence of heart disease in women after menopause. Phytoestrogens are found in various herbal sources and are considered as an alternative to hormone therapy because of structural similarity with oestrogen. Elaeagnus angustifolia L., known as Senjed in Persian, is used in Iranian traditional medicine with various medicinal properties, contains valuable compounds, including two types of phytoestrogens. The aim of the present study was to investigate the efficacy of E. angustifolia fruit on the cardiovascular function, lipid and glycaemic profiles in postmenopausal women. ⋯ E. angustifolia was somewhat effective in improving cardiovascular function and lipid profile, as well as the overall health of postmenopausal women. However, the use of isomalt and corn starch in menopausal women needs further investigation.