International journal of clinical practice
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Int. J. Clin. Pract. · Apr 2021
Observational StudyRisk factors associated with the incidence and recurrence of hyperkalaemia in patients with cardiorenal conditions.
Hyperkalaemia (HK) is associated with increased mortality risk. Prior studies suggest that the causes of HK are multifactorial. This study aimed to examine risk factors for incident and recurrent HK in six large real-world cohorts of UK patients that could be considered at elevated HK risk because of underlying disease pathology and/or medication use. ⋯ Several risk factors for HK that are easily measured in routine clinical practice were identified, facilitating the identification of patients who are at the highest risk of experiencing HK, including recurrent HK.
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Int. J. Clin. Pract. · Apr 2021
Assessing the Spread of the Novel Coronavirus In The Absence of Mass Testing.
Assessing why the spread of the COVID-19 virus slowed down in many countries in March through to May of 2020 is of great significance. The relative role of restrictions on behaviour ("lockdowns") and of a natural slowing for other reasons is difficult to assess when mass testing was not widely done. This paper assesses the evolution of the spread of the COVID-19 virus over this period when there was no data on test results for a large, random sample of the population. ⋯ Our findings suggest that the infection may have spread far enough in many countries by April 2020 to have been a significant factor behind the fall in measured new cases. Government restrictions on behaviour-lockdowns-were only one factor behind slowing in the spread of the virus.
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Int. J. Clin. Pract. · Apr 2021
Relationship between lymphovascular invasion and molecular subtypes in invasive breast cancer.
The aim of this study is to evaluate the relation between LVI and molecular subtypes in invasive breast cancers and to find out whether LVI which is a histopathologic indicator has a role in subtype classification or not. ⋯ As a result, we found that LVI can affect molecular subtypes. This showed that a histopathological factor may affect tumour biology. In other words, breast cancer is a heterogeneous disease with many different predictors and prognostic variables.
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Int. J. Clin. Pract. · Apr 2021
Meta AnalysisSafety and Efficacy of High Power Shorter duration Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Radiofrequency ablation in patients with atrial fibrillation (AF) is effective but hampered by pulmonary veins reconnection because of insufficient lesions. High power shorter duration ablation (HPSD) was seen to increase efficacy and safety. This analysis aimed to evaluate the clinical benefits of HPSD in patients with AF. ⋯ HPSD was safe and efficient for treating AF with clear advantages of procedural features, it also showed benefits of higher first-pass PVI and reducing recurrence of atrial arrhythmias compared with the LPLD. Moreover, major complications and ETI were similar between two groups.
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Int. J. Clin. Pract. · Apr 2021
Observational StudyImplicaciones pronosticas de la Anemia en pacientes con Insuficiencia Cardiaca Aguda atendidos en Servicios de Urgencias Hospitalarios. Estudio ANEM-ICA.
The presence of anaemia leads to a worse prognosis in patients with heart failure (HF). There are few data on the impact of anaemia on mortality in patients with acute heart failure (AHF), and the studies available are mainly retrospective, and include hospitalised patients. ⋯ Anaemia is an independent predictor of mortality at 30 days and 1 year in patients with AHF attended in HEDs. It is important to study the aetiology of AHF since adequate treatment would reduce mortality.