International journal of clinical practice
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Int. J. Clin. Pract. · Jun 2021
Importance of COX-2 Expression in Wilms' Tumor: A Preliminary Study.
In Wilms' tumour (WT), secondary malignancies caused by the side effects of intensive treatments remain one of the important problems. Therefore, there is a need for new studies to identify low- and high-risk groups for WT and to improve the treatment regimens of children in the low-risk group. In our study, we aimed to determine the prognostic significance of the cyclooxygenase-2 (COX-2) biomarker in WT. ⋯ In our study, no significant relationship was found between significant prognostic parameters and COX-2 expression. Since COX-2 expression was observed in almost all patients, we consider that the COX-2 pathway is effective during the development phase of WT.
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Int. J. Clin. Pract. · Jun 2021
Observational StudyThe incidence of inadvertent perioperative hypothermia in patients undergoing general anesthesia and an examination of risk factors.
Unintended perioperative hypothermia, defined as core body temperature less than 36°C, is closely related to many complications such as cardiovascular diseases, peroperative hemorrhagic diathesis and impairment of drug metabolism. Determination of the incidence of perioperative hypothermia and examination of risk factors may help to prevent hypothermia and its complications. ⋯ The incidence of perioperative hypothermia found was high. Important risk factors were found as prolonged duration of anesthesia and surgery, advanced age, overweight, high ASA scores, major surgeries, endoscopic operations and unwarmed fluid administration. High incidence may be reduced by raising awareness, considering fossible risk factors and following the recommendations of the guidelines on prevention of perioperative hypothermia.
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Int. J. Clin. Pract. · Jun 2021
Factors influencing quality of life over a 4-year period of time in Romanian patients with diabetes mellitus.
To evaluate the changes in quality of life (QOL), diabetic neuropathy (DN) and amputations over 4 years in patients with diabetes. ⋯ QOL deteriorates with age and DD. Norfolk QOL-DN subscale scores can predict amputations.
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Int. J. Clin. Pract. · Jun 2021
The Prognostic Impact of Thyroid Disorders on the Clinical Severity of COVID-19: Results of Single Center Pandemic Hospital.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause thyroid hormonal disorders. In addition, tracheal compression by thyroid nodules can aggravate hypoxia in critically ill patients. No studies have investigated the effect of thyroid nodules on the prognosis of patients with COVID-19. In this study, we investigated the effect of thyroid hormonal disorders and thyroid nodules on the prognosis of patients with COVID-19. ⋯ Overt thyroid hormonal disorders were more common in critically ill COVID-19 patients. FT3 level at hospital admission is a potential prognostic marker of COVID-19 patients. Thyroid nodules may be associated with severe COVID-19 disease.