The British journal of surgery
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Randomized Controlled Trial Multicenter Study
Randomized clinical trial of mast cell inhibition in patients with a medium-sized abdominal aortic aneurysm.
Abdominal aortic aneurysm (AAA) is thought to develop as a result of inflammatory processes in the aortic wall. In particular, mast cells are believed to play a central role. The AORTA trial was undertaken to investigate whether the mast cell inhibitor, pemirolast, could retard the growth of medium-sized AAAs. In preclinical and clinical trials, pemirolast has been shown to inhibit antigen-induced allergic reactions. ⋯ NCT01354184 (https://www.clinicaltrials.gov).
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Randomized Controlled Trial
Tumour regression in the randomized Stockholm III Trial of radiotherapy regimens for rectal cancer.
The Stockholm III Trial randomized patients with primary operable rectal cancers to either short-course radiotherapy (RT) with immediate surgery (SRT), short-course RT with surgery delayed 4-8 weeks (SRT-delay) or long-course RT with surgery delayed 4-8 weeks. This preplanned interim analysis examined the pathological outcome of delaying surgery. ⋯ Short-course RT induces tumour downstaging if surgery is performed after an interval of 4-8 weeks.