Neuromodulation : journal of the International Neuromodulation Society
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Randomized Controlled Trial
Enhancement of affective processing induced by bifrontal transcranial direct current stimulation in patients with major depression.
Our aim was to evaluate whether one single section of transcranial direct current stimulation (tDCS), a neuromodulatory technique that noninvasively modifies cortical excitability, could induce acute changes in the negative attentional bias in patients with major depression. ⋯ Active but not sham tDCS significantly modified the negative attentional bias. These findings add evidence that a single tDCS session transiently induces potent changes in affective processing, which might be one of the mechanisms of tDCS underlying mood changes.
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This study aims to investigate the influence of deep brain stimulation (DBS) on caregiver burden and quality of life in Parkinson's disease. ⋯ Although there were several limitations to this study, DBS seems to improve quality of life without significantly increasing caregiver burden.
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Multicenter Study Observational Study
Peripheral nerve field stimulation (PNFS) in chronic low back pain: a prospective multicenter study.
The goal of this study was to evaluate the long-term efficacy and safety of peripheral nerve field stimulation (PNFS) for chronic low back pain (cLBP). ⋯ This prospective, multicenter study confirms that PNFS is an effective therapy for the management of cLBP. Significant improvements in many aspects of the pain condition were measured, and complications were minimal.
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Spinal cord stimulation (SCS) is used for treating intractable neuropathic pain. Generally, it induces paresthesia in the area covered by SCS. Burst SCS was introduced as a new stimulation paradigm with good pain relief without causing paresthesia. Good results have been obtained in patients who were naive to SCS. In this study we assess the effectiveness of burst stimulation in three groups of chronic pain patients who are already familiar with SCS and the accompanying paresthesia. ⋯ About 60% of the patients with tonic SCS experienced further pain reduction upon application of burst stimulation.