Neuromodulation : journal of the International Neuromodulation Society
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Clinical Trial
Safety and efficacy of vagus nerve stimulation paired with tones for the treatment of tinnitus: a case series.
Classical neuromodulation applies current to the nervous system in an attempt to alter ongoing activity. However, classical neuromodulation interferes with activity but does not drive it in a controlled way. Recently, an animal study demonstrated it is possible to drive plasticity in a controlled way by using stimulation of the vagus nerve paired with tones. This reversed the tinnitus percept and pathological neural plasticity in noise-exposed rats with behavioral characteristics of tinnitus. The aim of the current study was to translate this innovative neuromodulation method to humans suffering from tinnitus. ⋯ VNS paired with tones excluding the tinnitus-matched frequency is safe and feasible. It seems to exert a beneficial effect in nonmedication-taking patients, both with regard to the perceived sound and the distress. Further studies are therefore mandated.
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This study aims to investigate the influence of deep brain stimulation (DBS) on caregiver burden and quality of life in Parkinson's disease. ⋯ Although there were several limitations to this study, DBS seems to improve quality of life without significantly increasing caregiver burden.
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We developed a custom-made miniaturized neural stimulation system with a liquid crystal polymer (LCP)-based electrode array for animal experiments. In order to verify the feasibility of the system, motor cortex stimulation (MCS) was applied on the rat pain model induced by sciatic nerve injury. ⋯ We developed a miniaturized electrical stimulation system with a novel flexible LCP electrode array for MCS in rats. This system is expected to be used in studying various neurological diseases and examining in vivo brain function.
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Letter Case Reports
Catastrophic failure of a Boston Scientific Artisan spinal cord stimulator.
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Letter Case Reports
How to avoid Twiddler's syndrome in deep brain stimulation for dystonia?