Ulus Travma Acil Cer
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Ulus Travma Acil Cer · Dec 2022
Effect of L-carnitine on regeneration in experimental partial hepatectomy model in rats.
In cases of major liver resections or ischemic damage made by the pringle maneuver, agents that increase regeneration or manage ischemic reperfusion injury have become a fascinating topic for researchers. The aim of this study is to see how systemic L-carnitine, an antioxidant with thorough research behind it, affects liver regeneration after major hepatectomy in a rat experimental hepatectomy (two-thirds liver resection) model. ⋯ It is thought that L-carnitine, whose many positive effects have been shown experimentally and clinically, has a positive effect on liver regeneration and immunohistochemical researches is required to elucidate this pathway.
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Ulus Travma Acil Cer · Dec 2022
Effect of pheniramine maleate on rat skeletal muscle ischemia-reperfusion injury.
Skeletal muscle ischemia-reperfusion injury (IRI) is a common clinical problem encountered after tourniquet ap-plication or replantation. This study investigated the effect of pheniramine maleate (Ph), which is frequently used in clinical practice to reduce IRI, and compared its efficacy in IRI with N-acetylcysteine (NAC), a molecule that has been shown to be effective in IRI. ⋯ Ph is effective at reducing experimental rat skeletal muscle IRI.
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Ulus Travma Acil Cer · Dec 2022
Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.
Acute pancreatitis (AP) is inflammation of pancreas in which pancreas enzymatic activity is increased. Parasym-pathetic innervation of pancreas plays an important role in several functions of pancreas. Botulinum toxin (BTx) might be a tool to suppress the pancreas activity in AP. ⋯ Administration of intraductal BTx suppressed the AP without making significant suppression in endogenous activity of pancreas.
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Ulus Travma Acil Cer · Dec 2022
Are the cytokines and chemokines important for the early diagnosis of mesenteric ischemia?
Acute mesenteric ischemia (AMI) has very high mortality and morbidity rates, and the most important factor in the prognosis of AMI is the duration of ischemia. This study aims to evaluate the changes of these markers according to the ischemia duration and possible use of cytokines and chemokines in the early diagnosis of AMI. ⋯ The increased levels of CXCL1, MCP-1, TNF-α, and IL-6, which had a high correlation with the duration of ischemia in patients with intestinal ischemia, may help clinicians with diagnoses and treatment decision-making.