World Neurosurg
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Glioma is the most common malignant brain tumor in neurosurgery. Bevacizumab (BEV) is a monoclonal antibody that inhibits tumors by inhibiting vascular endothelial growth factor and reducing tumor angiogenesis. To evaluate the efficacy and safety of BEV combined with temozolomide (TMZ) in glioma, we performed a meta-analysis. ⋯ The combination of TMZ and BEV can improve PFS as well as overall response rate in patients and has no benefit on OS. At the same time, the adverse reactions during the combination of the 2 drugs were acceptable.
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There has been an increased focus on patient involvement in health care worldwide, with studies showing that involving patients in their treatment and care is associated with positive outcomes. However, there is a dearth of knowledge about inpatient preferences and experiences of involvement in neurosurgery in Scandinavian countries. This study aimed to identify inpatients' preferences regarding their involvement in their treatment and the extent to which they experienced being involved in their treatment and care during admission. ⋯ The patients mostly preferred shared decision-making about their treatment during hospitalization and generally reported high involvement in their treatment and care. The results showed a desire for improved information sharing and dialog among healthcare professionals, patients, and relatives.
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To determine the association between Modic changes (MCs) with other magnetic resonance imaging parameters and clinical symptoms of cervical degenerative disc disease. ⋯ The factor predicting MC type 2 at the C3-C7 cervical levels is submaximal damage to the endplate. The MC rate is increased due to MC type 1 and MC type 2. MC types at the cervical levels may not represent consecutive stages of the same process.
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The wide variability in the efficacy of Gamma Knife surgery (GKS) treating trigeminal neuralgia type 1 (TN1) has not been completely elucidated. We aimed to investigate the association between outcomes of TN1 and the radiosurgical biologically effective dose (BED) on the specific part of the trigeminal root. ⋯ The efficacy and safety of GKS treating TN1 may depend on the sufficient coverage of high BED on the division affected by pain and tolerated BED on the root entry zone.
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To analyze the literature regarding the use of stereotactic radiosurgery as the primary treatment of vestibular schwannoma to further evaluate efficacy and treatment-related neurologic deficits. ⋯ Stereotactic radiosurgery is a safe and effective primary treatment modality for sporadic vestibular schwannoma as shown by the present analysis. Radiosurgery is effective regarding tumor control and hearing preservation and offers a low rate of posttreatment facial nerve dysfunction.