The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · May 2013
Randomized Controlled Trial Comparative Study Clinical TrialComparison of postprandial profiles of ghrelin, active GLP-1, and total PYY to meals varying in fat and carbohydrate and their association with hunger and the phases of satiety.
The relationship between postprandial peptides at circulating physiological levels and short-term appetite control is not well understood. ⋯ The results demonstrate that under these conditions, these peptides respond differently to ingested nutrients. Ghrelin and GLP-1, but not PYY, were associated with short-term control of appetite over the measurement period.
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J. Clin. Endocrinol. Metab. · May 2013
Randomized Controlled Trial Comparative Study Clinical TrialDesiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study.
Patients previously treated with desiccated thyroid extract (DTE), when being switched to levothyroxine (L-T₄), occasionally did not feel as well despite adequate dosing based on serum TSH levels. ⋯ DTE therapy did not result in a significant improvement in quality of life; however, DTE caused modest weight loss and nearly half (48.6%) of the study patients expressed preference for DTE over L-T₄. DTE therapy may be relevant for some hypothyroid patients.