The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Oct 2015
Randomized Controlled Trial Multicenter StudySteroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program.
Steroid sex hormones and SHBG may modify metabolism and diabetes risk, with implications for sex-specific diabetes risk and effects of prevention interventions. ⋯ Estrogens and T predicted diabetes risk in men but not in women. SHBG and its polymorphisms did not predict risk in men or women. Diabetes risk is more potently determined by obesity and glycemia than by sex hormones.
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J. Clin. Endocrinol. Metab. · Oct 2015
Randomized Controlled TrialFGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival.
Critical illness is hallmarked by mitochondrial damage, which is attenuated by targeting normoglycemia. Mitochondrial dysfunction induces fibroblast growth factor-21 (FGF21) via the integrated stress response (ISR). ⋯ Critical illness is a potent inducer of serum FGF21 and of liver fgf21 expression, possibly driven at least in part by mitochondrial damage and the ISR, which were all attenuated by targeting normoglycemia.