Pak J Pharm Sci
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Randomized Controlled Trial
Effect of propofol and sevoflurane on cognitive function among elderly patients undergoing elective surgery under anesthesia.
The objective of present study was to compare the effect of propofol and sevoflurane on cognitive function among elderly patients undergoing elective surgery under anesthesia. Elderly patient who met eligibility criteria were randomized to receive Intravenous anesthetic (propofol) or Inhalation anesthetic (sevoflurane, Group II) in allocation ratio of 1:1. The following variables were assessed, 1) recovery time; 2) measurement of attention and psychomotor functions; 3) memory (verbal memory); 4) obvious memories during anesthesia assessed by remembrance (recall) and recognition tests. ⋯ Similar trend of results was observed between both the groups after 120 minutes of anesthesia (delayed test). Moreover, the patients who were treated with propofol had better memory score as compared to patients treated with sevoflurane. The difference was statistically significant between both the treatment groups in both type of recognition test (immediate and delayed recognition test) [p<0.005].