The Journal of urology
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The Journal of urology · Feb 2002
Randomized Controlled Trial Clinical TrialEvaluation of octylcyanoacrylate for wound repair of clinical circumcision and human skin incisional healing in a nude rat model.
Alternative methods of circumcision wound closure have been studied to decrease repair time and complications, and improve cosmesis. This study includes a clinical and a laboratory research portion. Clinical parameters, wound outcome, closure time and operative time were compared for octylcyanoacrylate and suture approximation of circumcision incisions. An in vivo incisional model using human foreskin was used to compare the wound breaking strength of octylcyanoacrylate and suture repair. ⋯ Circumcision wounds may be closed by octylcyanoacrylate with shorter wound closure and operative time than by suture. In an animal model of human skin healing, wound breaking stress after octylcyanoacrylate closure was equivalent to suture repair. Octylcyanoacrylate may be a useful alternative to suture closure for circumcision incisions.
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The Journal of urology · Jan 2002
Randomized Controlled Trial Comparative Study Clinical TrialTamsulosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects.
We systematically reviewed the effectiveness and adverse effects of tamsulosin for lower urinary tract symptoms compatible with benign prostatic obstruction. ⋯ Tamsulosin improves lower urinary tract symptoms and flow. Its effectiveness was similar to that of other alpha-antagonists, increasing slightly at higher doses. Adverse effects were generally mild but the incidence, including treatment withdrawals, increased substantially at higher doses.
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The Journal of urology · Oct 2001
Randomized Controlled Trial Comparative Study Clinical TrialLocal anesthesia for ultrasound guided prostate biopsy: a prospective randomized trial comparing 2 methods.
Since the introduction of prostate specific antigen (PSA) screening, asymptomatic men often undergo transrectal ultrasound guided prostate biopsy. This procedure may cause significant discomfort, which may limit the number of biopsies. We performed a randomized prospective study to compare periprostatic infiltration with 1% lidocaine with intrarectal instillation of 2% lidocaine gel before prostate biopsy. ⋯ Men should have the opportunity to receive local anesthesia before ultrasound guided prostate biopsy with the goal of decreasing the discomfort associated with this procedure. Our prospective randomized study indicates that ultrasound guided periprostatic nerve block with 1% lidocaine provides anesthesia superior to the intrarectal placement of lidocaine gel.
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The Journal of urology · Aug 2001
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialRandomized comparative study of 3 versus 8-month neoadjuvant hormonal therapy before radical prostatectomy: biochemical and pathological effects.
A prospective phase 3 trial was initiated to determine whether 8 compared with 3-month neoadjuvant hormonal therapy reduces prostate specific antigen (PSA) recurrence rates after radical prostatectomy. Our interim analysis includes secondary end points of differences in biochemistry, pathology and adverse events between the 2 groups. ⋯ Ongoing biochemical and pathological regression of prostate tumors occurs between 3 and 8 months of neoadjuvant hormonal therapy, suggesting that the optimal duration of neoadjuvant hormonal therapy is longer than 3 months. Longer followup is needed to determine whether longer therapy alters PSA recurrence rates.
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The Journal of urology · Jul 2001
Randomized Controlled Trial Comparative Study Clinical TrialA crossover randomized trial of transcutaneous electrical nerve stimulation and oxybutynin in patients with detrusor instability.
Management of idiopathic detrusor instability is difficult in most patients mainly due to the lack of a complete understanding of the pathophysiology. Oxybutynin and transcutaneous electrical nerve stimulation have been used but to our knowledge no direct comparisons have been made. ⋯ Both treatments clearly improved subjective parameters. However, only oxybutynin showed significant improvements in objective urodynamic parameters. Transcutaneous electrical nerve stimulation can be used in patients who cannot take oxybutynin. Further studies are needed to show the long-term efficacy and cost analyses of nerve stimulation.