Arch Pediat Adol Med
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Arch Pediat Adol Med · Oct 2007
Review Meta AnalysisHypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review.
To systematically review the effectiveness, as determined by survival without moderate to severe neurodevelopmental disability in infancy and childhood, and the safety of hypothermia vs normothermia in neonates with postintrapartum hypoxic-ischemic encephalopathy and to perform subgroup analyses based on severity of encephalopathy (moderate or severe), type of hypothermia (systemic or selective head cooling), and degree of hypothermia (moderate [
or=33.6 degrees C]). ⋯ In neonates with postintrapartum asphyxial hypoxic-ischemic encephalopathy, hypothermia is effective in reducing death and moderate to severe neurodevelopmental disability either in combination or separately and is a safe intervention. -
Arch Pediat Adol Med · Jun 2004
Review Meta Analysis Comparative StudyEfficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis.
To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever. ⋯ In children, single doses of ibuprofen (4-10 mg/kg) and acetaminophen (7-15 mg/kg) have similar efficacy for relieving moderate to severe pain, and similar safety as analgesics or antipyretics. Ibuprofen (5-10 mg/kg) was a more effective antipyretic than acetaminophen (10-15 mg/kg) at 2, 4, and 6 hours posttreatment.
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Arch Pediat Adol Med · May 2004
Meta Analysis Comparative StudyEnteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials.
To review the relative efficacy and safety of enteral vs intravenous (IV) rehydration therapy in treating childhood gastroenteritis. ⋯ For childhood gastroenteritis, enteral rehydration is as effective if not better than IV rehydration. Enteral rehydration by the oral or nasogastric route is associated with significantly fewer major adverse events and a shorter hospital stay compared with IV therapy and is successful in most children.