British medical bulletin
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British medical bulletin · Jul 2022
ReviewTackling organ donation among minority ethnic communities in the UK-a whole systems approach.
There are inequalities experienced by minority ethnic groups in the UK in organ donation and transplant services, with significant variation in relation to demand for, access to and waiting times for these services. ⋯ Improved access to transplantation and reduced waiting times can be achieved to increase the number of organ donors from minority ethnic groups if there are concerted and adequately resourced culturally competent interventions with concomitant evaluation programmes.
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'Assisted dying' is practiced in some European countries and US states. Legislation suggests that there exists an easily prescribed drug which consistently brings about death quickly and painlessly. Evidence from jurisdictions where 'assisted dying' is practiced, however, reveals that hastening patient death is not so simple. ⋯ In order to properly assess the efficacy and safety of 'assisted dying', a more thorough means of data collection regarding the drugs used must be implemented and research is urgently needed into their mode of action.
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British medical bulletin · Jul 2022
ReviewSmall interfering RNAs in the management of human rheumatoid arthritis.
Rheumatoid arthritis (RA) has unclear pathogenesis, but the molecules that feed its inflammatory state are known. Small interfering RNAs (siRNAs) are useful to identify molecular targets and evaluate the efficacy of specific drugs, and can themselves be used for therapeutic purposes. ⋯ To date, it is not possible to determine whether the pharmacological response of siRNAs on cells in vitro would be similar to what takes place in vivo for the diseases studied so far.
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British medical bulletin · Jul 2022
Hamstring, bone-patellar tendon-bone, quadriceps and peroneus longus tendon autografts for primary isolated posterior cruciate ligament reconstruction: a systematic review.
Several autografts are available to reconstruct the posterior cruciate ligament (PCL). ⋯ All autografts are viable options for PCL reconstruction, with BTB and hamstring autografts demonstrating superior PROMs. However, further clinical investigations are required to determine the ideal autograft construct.