British medical bulletin
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British medical bulletin · Mar 2024
ReviewQuality of life of family carers of people living with dementia: review of systematic reviews of observational and intervention studies.
Family members are the primary source of support for the growing number of people living with dementia (PLWD) worldwide. However, caring for a person living with dementia can have detrimental impacts on the carer quality of life (QoL). This review of systematic reviews explored the factors associated with the QoL of family carers of PLWD and interventions aimed at improving their QoL. ⋯ Future research should be focused on understanding how to best implement and measure person-centred care approaches to carer QoL, including cost-effectiveness. More qualitative studies are necessary to explore carer negative and positive experiences of QoL.
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British medical bulletin · Mar 2024
ReviewGenetics in Parkinson's disease, state-of-the-art and future perspectives.
Parkinson's disease (PD) is the second most common neurodegenerative disorder and is clinically characterized by the presence of motor (bradykinesia, rigidity, rest tremor and postural instability) and non-motor symptoms (cognitive impairment, autonomic dysfunction, sleep disorders, depression and hyposmia). The aetiology of PD is unknown except for a small but significant contribution of monogenic forms. ⋯ The application of PRS and integrated multi-omics in PD promises to improve the personalized care of patients.
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British medical bulletin · Dec 2023
ReviewInterventions to tackle health inequalities in cardiovascular risks for socioeconomically disadvantaged populations: a rapid review.
Cardiovascular disease (CVD) has shown significant health inequalities for people with low socioeconomic status associated with more risk factors. This review was to synthesize interventions that targeted CVD risks and outcomes among socioeconomically disadvantaged populations and to understand the impact associated with these interventions. ⋯ Research is needed with mixed evidence using real world evaluation and lived experience combined with health economic evaluation, on both mental and physical health outcomes.
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Participant recruitment to clinical trials is often sub-optimal. Decentralized clinical trials have the potential to address challenges in traditional site-based clinical trial recruitment. ⋯ The focus of development must ensure that the overall impact will widen participation and reduce inequalities in healthcare.
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British medical bulletin · Dec 2023
ReviewElevated mortality among the second-generation (children of migrants) in Europe: what is going wrong? A review.
The 'second-generation' (i.e. the children of migrants) represent one of the fastest growing subpopulations of the child and young adult populations in Europe today. The research so far appears to indicate that their mortality risk is elevated relative to people with non-migrant backgrounds. ⋯ Place more emphasis on the complexity of migration background, specific causes-of-death, and understanding the roles of explanatory factors beyond socioeconomic background.