British medical bulletin
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Polycystic ovary syndrome (PCOS) is a common condition characterized by reproductive, hyperandrogenic and dysmetabolic features, and often becomes clinically manifest during adolescence, particularly with weight-gain. ⋯ A challenge for the future is to explore a role for epigenetic modifications in the development of PCOS, and implications for the in utero environment and novel therapeutic opportunities.
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British medical bulletin · Jul 2022
ReviewSmall interfering RNAs in the management of human rheumatoid arthritis.
Rheumatoid arthritis (RA) has unclear pathogenesis, but the molecules that feed its inflammatory state are known. Small interfering RNAs (siRNAs) are useful to identify molecular targets and evaluate the efficacy of specific drugs, and can themselves be used for therapeutic purposes. ⋯ To date, it is not possible to determine whether the pharmacological response of siRNAs on cells in vitro would be similar to what takes place in vivo for the diseases studied so far.
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British medical bulletin · Jul 2022
ReviewTackling organ donation among minority ethnic communities in the UK-a whole systems approach.
There are inequalities experienced by minority ethnic groups in the UK in organ donation and transplant services, with significant variation in relation to demand for, access to and waiting times for these services. ⋯ Improved access to transplantation and reduced waiting times can be achieved to increase the number of organ donors from minority ethnic groups if there are concerted and adequately resourced culturally competent interventions with concomitant evaluation programmes.
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British medical bulletin · Jul 2022
Hamstring, bone-patellar tendon-bone, quadriceps and peroneus longus tendon autografts for primary isolated posterior cruciate ligament reconstruction: a systematic review.
Several autografts are available to reconstruct the posterior cruciate ligament (PCL). ⋯ All autografts are viable options for PCL reconstruction, with BTB and hamstring autografts demonstrating superior PROMs. However, further clinical investigations are required to determine the ideal autograft construct.
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British medical bulletin · Mar 2022
Review'The WOW factors': comparing workforce organization and well-being for doctors, nurses, midwives and paramedics in England.
High rates of poor mental health in healthcare staff threatens the quality and sustainability of healthcare delivery. Multi-factorial causes include the nature and structure of work. We conducted a critical review of UK NHS (England) data pertaining to: doctors, nurses, midwives and paramedics. ⋯ Multi-level systems approaches to well-being are required that consider intersectionality and structural differences between professions; together with inter-professional national databases to facilitate monitoring.