Turk J Gastroenterol
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Turk J Gastroenterol · Dec 2009
Randomized Controlled Trial Comparative StudySedation with midazolam versus midazolam plus meperidine for routine colonoscopy: a prospective, randomized, controlled study.
The major goals of analgesia and sedation are to provide pain control and anxiolysis and to facilitate therapeutic and diagnostic interventions. A combination of midazolam and an opioid is usually administered to achieve sedation and analgesia during colonoscopy. However, the value of adding analgesics to sedative agents has not been well evaluated. In this study, we compared the efficacy and safety of midazolam versus midazolam plus meperidine for colonoscopy. ⋯ Patient safety, outcomes, and satisfaction are similar in colonoscopy procedures performed under sedation protocols using either midazolam and meperidine or midazolam alone. Although endoscopists favor the use of both medications together, adding meperidine to midazolam before the colonoscopy does not seem to have additive beneficial effect for the patients.