Turk J Gastroenterol
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Turk J Gastroenterol · Oct 2011
Meta AnalysisEfficacy evaluation of imatinib in the treatment of patients with gastrointestinal stromal tumors.
Published data on the dose of imatinib to treat gastrointestinal stromal tumors seemed inconclusive. To derive a more precise estimation of dose of imatinib to treat gastrointestinal stromal tumors, a meta-analysis was performed. ⋯ The meta-analysis indicated that cumulative response for patients with low-dose imatinib showed no significant difference compared with that with high-dose imatinib. However, high-dose imatinib brought patients more toxic effect and more dosage adjustment for down regulation was made for these patients with severe toxic effect. With long follow-up of the patients, result of neither progression-free survival nor overall survival reached statistical significance between low-dose arm and high-dose arm.