Turk J Gastroenterol
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Turk J Gastroenterol · Dec 2014
Randomized Controlled Trial Comparative StudyKetamine versus alfentanil combined with propofol for sedation in colonoscopy procedures: a randomized prospective study.
Different drug combinations are used for sedation in colonoscopy procedures. A ketamine-propofol (ketofol) mixture provides effective sedation and has minimal adverse effects. Alfentanil also provides anesthesia for short surgical procedures by incremental injection as an adjunct. However, no study has investigated the use of ketofol compared with an opioid-propofol combination in colonoscopic procedures. ⋯ Ketofol provided better hemodynamic stability and quality of sedation compared with alfentanil-propofol combination in elective colonoscopy, and required fewer additional propofol; however, it prolonged discharge time. Both combinations can safely be used in colonoscopy sedation.