Gac Med Mex
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In Colombia, gastric cancer is fifth in incidence (12.8 cases per 100,000) and third in mortality (9.9 cases per 100,000). Microsatellite instability (MSI), a phenotype in gastric cancer treatment, lacks comprehensive exploration in Colombian and Hispanic/Latino populations. Data scarcity hinders immunotherapy approval in middle-income countries. ⋯ Prior studies report 22% MSI phenotype prevalence in gastric tumors, mostly in developed countries, excluding Hispanic/Latino populations. Identifying the prevalence of MSI in our population as 12.26% could pave the way for approving immune blockade drugs as a treatment option for these patients in Latin American countries. Our data could be utilized to conduct cost-utility studies in support of this.
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Historical Article
The secrets of the Tübingen Castle kitchen: Friedrich Miescher and the discovery of nuclein, the cornerstone of DNA.
In 1869, Friedrich Miescher, born in Basel, Switzerland, discovered a previously unknown phosphorus-rich substance in the nuclei of pus cells. Conducting his research in a laboratory set up in the kitchen of Tübingen's medieval castle in Germany, and under the guidance by Professor Felix Hoppe-Seyler, Miescher primarily focused on the composition of cell nuclei. He obtained nuclear material by washing pus cells from surgical bandages provided by a nearby hospital. ⋯ He named this substance 'nuclein,' marking the first description of DNA. Miescher passed away long before Watson, Crick, Wilkins, and Franklin announced the precise role DNA played in cells in 1953. Through his discovery, Miescher laid the groundwork for all subsequent DNA research.
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Aging, urbanization, and lifestyle changes have fueled the non-communicable diseases (NCDs) epidemic. ⋯ LE-60 increases were not accompanied by reductions in disability due to functional decline, highlighting the need for healthcare strategies to enhance healthy aging.
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Aging in Mexico is heterogeneous considering the ethnic diversity and social inequality that prevails. The condition of ethnicity allows us to delve deeper into the social and health inequalities that do not allow for healthy aging. ⋯ It is necessary to address the needs of the older Indigenous and Afro-Mexican population who face an old age with greater social disadvantage and functional deterioration.