J Postgrad Med
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Randomized Controlled Trial
A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin.
Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication in diabetic mellitus patients due to chronic hyperglycemia, resulting in platelet hyperactivity and dyslipidemia. Alpha-lipoic acid (ALA) is a potent antioxidant which has antiplatelet activity and lipid-modulating characteristics and plays a major role in the prevention of disease progression. ⋯ ALA, an antioxidant, demonstrated a protective effect against DPN by the virtue of its inhibitory effect on platelet aggregation and lipid-modulating effects and was found to have good safety.
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Randomized Controlled Trial
Utility of interactive videogame in allaying preoperative anxiety in pediatric surgical patients - A randomized controlled study.
Non-pharmacological distraction using video games (VG) is still under-explored in pediatric surgical patients. ⋯ VG-based distraction effectively reduced preoperative anxiety in children undergoing elective surgeries.