Pak J Med Sci
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The objective of the study was to explore the presentation of symptoms in patients suffering from treatment-resistant mood disorder (TRMD), and associated clinical features, including age, gender, and comorbid conditions, that lead towards the development of treatment-resistant mood disorder. Furthermore, the study analyses the available psychotherapeutic treatment modalities and evidence-based non-medical treatment approaches for TRMD. ⋯ It was concluded that psychotherapeutic interventions in augmentation with pharmacological modalities enhance the efficacy of treatment.