Neurology
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Randomized Controlled Trial Multicenter Study
Treatment of restless legs syndrome with pregabalin: a double-blind, placebo-controlled study.
To assess the therapeutic efficacy, required dose, and tolerability of pregabalin in patients with idiopathic restless legs syndrome (RLS). ⋯ This study provides Class II evidence that pregabalin is effective for the treatment of restless legs syndrome and improves sleep architecture and periodic limb movements in placebo-unresponsive patients.