Neurology
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Multicenter Study
CT within 6 hours of headache onset to rule out subarachnoid hemorrhage in nonacademic hospitals.
To investigate whether staff radiologists working in nonacademic hospitals can adequately rule out subarachnoid hemorrhage (SAH) on head CT <6 hours after headache onset. ⋯ Our results support a change of practice wherein a lumbar puncture can be withheld in patients with a head CT scan performed <6 hours after headache onset and reported negative for the presence of SAH by a staff radiologist in the described nonacademic setting.
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Randomized Controlled Trial Multicenter Study Comparative Study
Reduced efficacy of sumatriptan in migraine with aura vs without aura.
To determine whether acute migraine treatment outcome is different in migraine with aura compared with migraine without aura. ⋯ This post hoc analysis of pooled data from multiple randomized trials indicates that sumatriptan is less effective as acute therapy for migraine attacks with aura compared with attacks without aura. In the single study of inhaled DHE, the treatment had similar efficacy for migraine attacks with and without aura. Different responses of migraine with vs without aura to acute therapies may provide insight into underlying migraine mechanisms and influence the choice of acute therapies for different types of migraine attacks.