Neurology
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Randomized Controlled Trial
Triptan-induced disruption of trigemino-cortical connectivity.
The 5-HT1B/D agonists (triptans) are specific headache medications that have no effect on pain as such. Although they are routinely used in the treatment of acute migraine attacks, the underlying mechanisms of action are still a matter of debate. ⋯ These data suggest that a specific functional inhibition of trigemino-cortical projections is one of the reasons that triptans, unlike pain killers, act highly specifically on headache and migraine but not pain as such.
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Randomized Controlled Trial
Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial.
To determine whether the tumor necrosis factor α inhibitor etanercept is well tolerated and obtain preliminary data on its safety in Alzheimer disease dementia. ⋯ This study shows Class I evidence that weekly subcutaneous etanercept is well tolerated in Alzheimer disease dementia.
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Randomized Controlled Trial Multicenter Study Comparative Study
Reduced efficacy of sumatriptan in migraine with aura vs without aura.
To determine whether acute migraine treatment outcome is different in migraine with aura compared with migraine without aura. ⋯ This post hoc analysis of pooled data from multiple randomized trials indicates that sumatriptan is less effective as acute therapy for migraine attacks with aura compared with attacks without aura. In the single study of inhaled DHE, the treatment had similar efficacy for migraine attacks with and without aura. Different responses of migraine with vs without aura to acute therapies may provide insight into underlying migraine mechanisms and influence the choice of acute therapies for different types of migraine attacks.