Neurology
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Randomized Controlled Trial Multicenter Study
Framing advance care planning in Parkinson disease: Patient and care partner perspectives.
Advance care planning (ACP) is a core quality measure in caring for individuals with Parkinson disease (PD) and there are no best practice standards for how to incorporate ACP into PD care. This study describes patient and care partner perspectives on ACP to inform a patient- and care partner-centered framework for clinical care. ⋯ ACP in PD may be influenced by patient and care partner perceptions and misperceptions, symptoms of PD (e.g., apathy, cognitive dysfunction, disease severity), and models of clinical care. Optimal engagement of patients with PD and care partners in ACP should proactively address misperceptions of ACP and utilize clinic teams and workflow routines to incorporate ACP into regular care.
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Multicenter Study
Nusinersen in later-onset spinal muscular atrophy: Long-term results from the phase 1/2 studies.
To report results of intrathecal nusinersen in children with later-onset spinal muscular atrophy (SMA). ⋯ This study provides Class IV evidence that nusinersen improves motor function in children with later-onset SMA.