Neurology
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Randomized Controlled Trial Multicenter Study
Framing advance care planning in Parkinson disease: Patient and care partner perspectives.
Advance care planning (ACP) is a core quality measure in caring for individuals with Parkinson disease (PD) and there are no best practice standards for how to incorporate ACP into PD care. This study describes patient and care partner perspectives on ACP to inform a patient- and care partner-centered framework for clinical care. ⋯ ACP in PD may be influenced by patient and care partner perceptions and misperceptions, symptoms of PD (e.g., apathy, cognitive dysfunction, disease severity), and models of clinical care. Optimal engagement of patients with PD and care partners in ACP should proactively address misperceptions of ACP and utilize clinic teams and workflow routines to incorporate ACP into regular care.
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Randomized Controlled Trial
Erenumab in chronic migraine with medication overuse: Subgroup analysis of a randomized trial.
To determine the effect of erenumab, a human anti-calcitonin gene-related peptide receptor monoclonal antibody, in patients with chronic migraine and medication overuse. ⋯ This study provides Class II evidence that erenumab reduces monthly migraine days at 3 months in patients with chronic migraine and medication overuse.
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Randomized Controlled Trial
Erenumab in chronic migraine: Patient-reported outcomes in a randomized double-blind study.
To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). ⋯ This study provides Class II evidence that for patients with CM, erenumab treatment improves HRQoL, headache impact, and disability.