Romanian journal of internal medicine = Revue roumaine de médecine interne
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Randomized Controlled Trial Clinical Trial
The effect of two antidiarrhoeal drugs on the psychosocial adjustment to illness in chronic functional diarrhoea.
Chronic functional diarrhea is an embarrassing symptom, causing the impairment of the quality of life. ⋯ Diosmectite and loperamide are both potent drugs for chronic functional diarrhea. Diosmectite has better effects on associated symptoms and some items of psychosocial adjustment to illness (distress, sexual activity and vocational environment).
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Randomized Controlled Trial Comparative Study Clinical Trial
Humalog Mix 25 in patients with type 2 diabetes which do not achieve acceptable glycemic control with oral agents: results from a phase III, randomized, parallel study.
Humalog Mix 25 (Mix 25) is a premixed insulin mixture of 25% lispro and 75% neutral protamine lispro. Insulin lispro is an analog of human insulin. It is created when the amino acids at positions 28 and 29 of the B-chain of insulin are reversed. The natural sequence in human insulin at this position is proline at B28 and lysine at B29. The pharmacokinetic and pharmacodynamic profiles of insulin lispro indicate that it is more rapid acting, and therefore more physiological mealtime insulin than regular human insulin. ⋯ When glycemic control can no longer be achieved by oral antidiabetic agents, treatment with insulin should be considered as the next therapeutic option. Mix 25 provided good overall glycemic control, as well as patient treatment satisfaction.
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Randomized Controlled Trial Comparative Study Clinical Trial
The effect of metoclopramide on antral emptying of a semisolid meal in patients with functional dyspepsia. A randomized placebo controlled sonographic study.
The aim of this study was to investigate the effect of metoclopramide on the antral emptying of a semisolid meal. Twenty-five patients with functional dyspepsia received in a prospective randomized trial either metoclopramide 10 mg t.i.d. (n = 14) or placebo (n = 11) for 7 days. The antral emptying was measured by real-time ultrasound with a 3.5 MHz probe from the antral area recordings in the aorto-mesenteric plane. ⋯ Antral emptying was accelerated by metoclopramide compared with placebo. Fasting antral emptying was not changed by metoclopramide and the postprandial antral area had a trend to decrease. These data suggest that the effect of metoclopramide is less due to the enhancement of antral motility but rather to the reduction of postprandial fundus relaxation.