Journal of toxicology. Clinical toxicology
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Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence. ⋯ Bupropion overdose may lead to recurrent seizures, hypoxia and death. Aggressive management of severe bupropion overdose is recommended.
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J. Toxicol. Clin. Toxicol. · Jan 1997
Multicenter Study Clinical TrialUnintentional childhood poisoning in athens: a mirror of consumerism?
To estimate the incidence of unintentional childhood injuries resulting from accidental poisonings in the Greater Athens area and to ascertain what fraction of this incidence could be linked to specified conditions, amenable to preventive interventions. ⋯ Unintentional childhood poisoning further reflects an interaction between inappropriate storage of consumer products and suboptimal supervision during the housekeeping hours of the day.
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J. Toxicol. Clin. Toxicol. · Jan 1997
Historical ArticleAnaleptic use in clinical toxicology: a historical appraisal.
The introduction and increasing popularity of the barbiturates during the first two decades of the 20th century was associated with a new life threatening toxicological problem: the barbiturate overdose. ⋯ Although barbiturate overdose mortality decreased to less than 1% using this strategy, it would take another 20 years before this technique was universally adapted. While analeptic therapies for the treatment of drug overdose have now been abandoned, one of these analeptics, methylphenidate, currently enjoys wide use in the treatment of attention deficit hyperactivity disorder.
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In the Pacific Northwest region of the US and in southwestern British Columbia, Canada, isolated cases of renal failure have occurred following ingestion of wild mushrooms. We report four cases in which toxic mushrooms were mistaken for the edible pine mushroom or matsutake (Tricholoma magnivelare). ⋯ Mushroom field guides warn against mistaking Amanita smithiana for pine mushrooms. They are similar in size, color and habitat. It appears possible that Amanita smithiana mushrooms were eaten instead of pine mushrooms in these cases.