Journal of toxicology. Clinical toxicology
-
J. Toxicol. Clin. Toxicol. · Jan 1997
Experimental studies of methemoglobinemia due to percutaneous absorption of sodium nitrite.
Methemoglobin formation caused by a liniment solution containing sodium nitrite (30 g/L and 140 g/L) was studied in rats with normal or abraded skin, by measuring the methemoglobin concentration before and after application of liniment solutions with differing nitrite concentration. ⋯ Each of these findings are characteristic of nitrite and they imply the percutaneous absorption of nitrite. Regardless of the nitrite concentration, the methemoglobin concentration was consistently higher in abraded skin than in normal skin.
-
Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence. ⋯ Bupropion overdose may lead to recurrent seizures, hypoxia and death. Aggressive management of severe bupropion overdose is recommended.
-
J. Toxicol. Clin. Toxicol. · Jan 1997
Multicenter StudyProspective multicenter evaluation of tramadol exposure.
Tramadol is a novel analgesic possessing both opiate and noradrenergic effects. Its low potential for abuse suggests increasing use, but there are limited data on the toxicity in overdose. ⋯ This study suggests significant neurologic toxicity from tramadol overdose. Serious cardiovascular toxicity was not seen.
-
J. Toxicol. Clin. Toxicol. · Jan 1997
Case ReportsPlacental transfer of N-acetylcysteine following human maternal acetaminophen toxicity.
To determine whether the antidote for acetaminophen poisoning, N-acetylcysteine, administered to pregnant women with acetaminophen toxicity, crosses the placenta and can be measured in the newborn circulation following delivery. ⋯ This is the first study documenting placental transfer of N-acetylcysteine in humans and provides impetus for research establishing a direct antidotal effect of N-acetylcysteine in the fetus.