Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Apr 2024
Endothelial function in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors is not related to cardiovascular risk assessed by SCORE2 algorithm.
Tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic myeloid leukemia (CML) but are endowed with negative effects on endothelial function. ⋯ Endothelial function in CML patients treated with TKIs was not related to cardiovascular risk based on SCORE2/SCORE2-OP algorithms but CML-specific factors, including duration of TKI treatment. FMSF-based assessment of skin microcirculation was a sensitive method for detecting the vascular effects of TKIs.
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Pol. Arch. Med. Wewn. · Mar 2024
Dietary salt intake in chronic kidney disease. Recent studies and their practical implications.
Epidemiological studies in the general population show that the level of dietary salt intake is associated with increases in blood pressure, cardiovascular events and mortality. Trial data show that reducing salt intake reduces blood pressure, cardiovascular events and mortality. On the basis of this evidence, the World Health Organization and other bodies recommend restricting salt intake. ⋯ However, these trials have typically used resource-intensive approaches to dietary salt reduction that are not suitable for routine clinical care and salt intake typically remains high in people with CKD. The OxSalt care bundle is a low-cost intervention that was demonstrated in the OxCKD1 trial to help people with CKD to lower their salt intake and could be applied in routine clinical practice.