The lancet. Diabetes & endocrinology
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Lancet Diabetes Endocrinol · May 2016
Randomized Controlled Trial Multicenter StudyMaternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial.
Maternal vitamin D status has been associated with bone mass of offspring in many, but not all, observational studies. However, maternal vitamin D repletion during pregnancy has not yet been proven to improve offspring bone mass in a randomised controlled trial. We aimed to assess whether neonates born to mothers supplemented with vitamin D during pregnancy have greater whole-body bone mineral content (BMC) at birth than those of mothers who had not received supplementation. ⋯ Arthritis Research UK, Medical Research Council, Bupa Foundation, and National Institute for Health Research.
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Lancet Diabetes Endocrinol · May 2016
Review Meta AnalysisEffects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis.
In patients with type 2 diabetes, sodium-glucose cotransporter-2 (SGLT2) inhibitors are known to reduce glucose concentrations, blood pressure, and weight, but to increase LDL cholesterol and the incidence of urogenital infections. Protection against cardiovascular events has also been reported, as have possible increased risks of adverse outcomes such as ketoacidosis and bone fracture. We aimed to establish the effects of SGLT2 inhibitors on cardiovascular events, death, and safety outcomes in adults with type 2 diabetes, both overall and separately for individual drugs. ⋯ National Health and Medical Research Council of Australia.
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Lancet Diabetes Endocrinol · May 2016
Observational StudyActive commuting and obesity in mid-life: cross-sectional, observational evidence from UK Biobank.
Physical inactivity is a leading cause of obesity and premature mortality. We aimed to examine the relation between active commuting and obesity in mid-life using objectively measured anthropometric data from UK Biobank. ⋯ UK Medical Research Council.