The lancet. Diabetes & endocrinology
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Lancet Diabetes Endocrinol · May 2016
Randomized Controlled Trial Multicenter StudyMaternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial.
Maternal vitamin D status has been associated with bone mass of offspring in many, but not all, observational studies. However, maternal vitamin D repletion during pregnancy has not yet been proven to improve offspring bone mass in a randomised controlled trial. We aimed to assess whether neonates born to mothers supplemented with vitamin D during pregnancy have greater whole-body bone mineral content (BMC) at birth than those of mothers who had not received supplementation. ⋯ Arthritis Research UK, Medical Research Council, Bupa Foundation, and National Institute for Health Research.